Synthesis and evaluation of chitosan manganese-ferrite nanoparticles as MRI contrast agent
نویسندگان
چکیده
(*) Corresponding Author e-mail: [email protected] ABSTRACT: Magnetic nanoparticles are the good choice for using in MRI as the contrast agent. Iron oxide particles such as magnetite (Fe3O4) or its oxidized form maghemite (γ-Fe2O3) are the most commonly employed in biomedical applications. In this study, we synthesized and optimized the preparation of chitosan manganese-ferrite nanoparticles (CMn-Fe nps) and evaluated its ability for the mice macrophage cells imaging with MRI. The core and hydrodynamic size of the nanoparticles was 54±27 nm and 149±48 nm respectively. The magnetization reached a saturation magnetization value of 95 emu/g. The MRI images showed that the liver and some other organs were accumulated the CMn-Fe nps and produced a negative contrast in images. CMn-Fe nps demonstrated that it is a good candidate for using as a contrast agent material in macrophage cells imaging with MRI.
منابع مشابه
Synthesis and evaluation of chitosan manganese-ferrite nanoparticles as MRI contrast agent
Magnetic nanoparticles are the good choice for using in MRI as the contrast agent. Iron oxide particles such as magnetite (Fe3O4) or its oxidized form maghemite (γ-Fe2O3) are the most commonly employed in biomedical applications. In this study, we synthesized and optimized the preparation of chitosan manganese-ferrite nanoparticles (CMn-Fe nps) and evaluated its ability for the mice macrophage ...
متن کاملSynthesis and evaluation of chitosan manganese-ferrite nanoparticles as MRI contrast agent
Magnetic nanoparticles are the good choice for using in MRI as the contrast agent. Iron oxide particles such as magnetite (Fe3O4) or its oxidized form maghemite (γ-Fe2O3) are the most commonly employed in biomedical applications. In this study, we synthesized and optimized the preparation of chitosan manganese-ferrite nanoparticles (CMn-Fe nps) and evaluated its ability for the mice macrophage ...
متن کاملSynthesis and Characterization of Chitosan Coated Manganese Zinc Ferrite Nanoparticles as MRI Contrast Agents
Manganese zinc ferrite nanoparticles (MZF NPs) were synthesized by using a direct, efficient and environmental friendly hydrothermal method. To improve the colloidal stability of MZF NPs for biomedical applications, NPs were coated with chitosan by ionic gelation technique using sodium tripolyphosphate (TPP) as crosslinker. The synthesized NPs were characterized by X ray diffraction (XRD) analy...
متن کاملSynthesis and Characterization of Multifunctional Chitosan-MnFe2O4 Nanoparticles for Magnetic Hyperthermia and Drug Delivery
Multifunctional nanoparticles composed of MnFe₂O₄ were encapsulated in chitosan for investigation of system to combine magnetically-triggered drug delivery and localized hyperthermia for cancer treatment with the previously published capacity of MnFe₂O₄ to be used as an efficient MRI contrast agent for cancer diagnosis. This paper focuses on the synthesis and characterization of magnetic MnFe₂O...
متن کاملSimultaneous diagnosis and drug delivery by silymarin-loaded magnetic nanoparticles
Objective(s): The aim of this work was to prepare and characterize magnetic nanoparticles (MNPs) as theranostic system to act simultaneously as drug carrier and MRI contrast agent. Chitosan-coated MNPs (CMNPs) were prepared and loaded with silymarin. Silymarin-loaded CMNPs were characterized with various techniques and their potential as MRI contrast agent was also evaluated. Materials and Meth...
متن کامل